questions about cloning/imaging

Can I clone from a system (C drive) that has the OS size of lets say 20GB on a 256GB SSD to another partitioned drive that might only be a 50GB partition?

In other words does the source drive and target drives have to be the same size for cloning irrespective of the size of the OS on the source drive.

I believe that I can image the source drive to another drive that are different sizes as long as the target drive is large enough for the image