Best Way to backup two disks / exclude folders from Disk Backup
My system has two drives, C: a SSD drive with the OS and other programs, and 
a larger separate HD for mostly data.
To back up both, if I understand correctly, I have to use System Backup to get the C: drive, and a Disk Backup for the drive.
Assuming this is the most efficient way to do this, is there a way for me to backup all of but exclude 3 large folders? This is with the Standard version of the software under Window 10 Pro.
Thank you.
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Yes, it is possible in disk backup:
List of files that won't be backed up are listed here in the registry of Windows:
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\BackupRestore\FilesNotToSnapshot
Aomei respects those entries. So that is a convenient way to exclude files or folders from the backup.
Examples:
f:\nb1\nb1.txt
f:\nb2\*.* /s
You can also try File Backup or File Synch with filter settings, excluding specific folders.